# Studies and reviews

> Semaglutide reading list | Real GLP-1 — The Real GLP-1 reading list: semaglutide trials and reviews covering weight loss, appetite mechanisms, cardiovascular and kidney outcomes, and safety.

**Reading list**

The weight result is the beginning of this list. The questions spread out from there.

## Where to begin

[STEP 1](https://pubmed.ncbi.nlm.nih.gov/33567185/) supplies the weight-loss comparison. My next stops would be [SELECT](https://pubmed.ncbi.nlm.nih.gov/37952131/) and [FLOW](https://pubmed.ncbi.nlm.nih.gov/38785209/) for the cardiovascular and kidney outcomes that widened my interest. The [heart-failure trial](https://pubmed.ncbi.nlm.nih.gov/37622681/) adds symptoms and physical limitations to the conversation.

The [rodent neural-pathway study](https://pubmed.ncbi.nlm.nih.gov/32213703/) is the most surprising appetite paper on this list to me. It sits beside a [mechanistic review](https://pubmed.ncbi.nlm.nih.gov/39728000/) and an [early human alcohol-use-disorder trial](https://pubmed.ncbi.nlm.nih.gov/39937469/), each asking a different question. For the cautions, start with the [safety review](https://pubmed.ncbi.nlm.nih.gov/34305810/) and the [SUSTAIN-6 cardiovascular and retinopathy findings](https://pubmed.ncbi.nlm.nih.gov/27633186/).

## References

[1] Once-Weekly Semaglutide in Adults with Overweight or Obesity https://pubmed.ncbi.nlm.nih.gov/33567185/
[2] Semaglutide lowers body weight in rodents via distributed neural pathways https://pubmed.ncbi.nlm.nih.gov/32213703/
[3] Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes https://pubmed.ncbi.nlm.nih.gov/37952131/
[4] Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/27633186/
[5] Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/38785209/
[6] Safety of Semaglutide https://pubmed.ncbi.nlm.nih.gov/34305810/
[7] Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity https://pubmed.ncbi.nlm.nih.gov/37622681/
[8] Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/39937469/
[9] Spotlight on the Mechanism of Action of Semaglutide https://pubmed.ncbi.nlm.nih.gov/39728000/

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On Real GLP-1, my interest in semaglutide’s published results runs from the scale to the less photogenic outcomes, and these essays offer no medical advice or treatment service.